Indapamide
| CAS No. | 26807–65–8 |
| Chemical Name | 4-chloro-N-[(2RS)-2-methyl-2,3-dihydro1Hindol-1-yl]- 3- sulphamoylbenzamide |
| Non propriety Names | ------ |
| Molecular Formula | C16H16ClN3O3S |
| Molecular Weight | 365.8 |
Product Specification
| Description | White or almost white powder. |
| Solubilit | Practically insoluble in water , soluble in alcohol ,acetonitrile, ethyl acetate |
| Identification i) IR ii) UV Absorption |
To comply To comply positively (Absorption max. at 242nm, 279nm & 287 nm) |
| Melting Point | Melts bet. 167 0 C-170 0 C |
| LOD (at 105 C 4hr.) | NMT 3.0 % |
| Sulphated ash | NMT 0.1 % |
| Chromatographic Purity by TLC |
|
| Residual organic solvents. Isopropyl alcohol Toluene Acetone (AS PER USP 31 SUPPLIMENT 2 JULY08) |
NMT 1000 ppm NMT 800 ppm NMT 400 ppm |
| Related substance By HPLC | Methylnitrosoindoline Not more than 5 ppm Indapamide impurity B NMT 0.3% Sum of all Impurities NMT 0.5% |
| Assay by HPLC | 98.0 % To 101.0 % w/w (ODB) |
| Therapeutic Category of these Drugs :- Diuretic, Antihypertensive | |
